top of page
< Back

In Situ Electrochemical Distance Tunneling Spectroscopy of ds-DNA Molecules

Author(s):

Emil Wierzbinski, Justin Arndt, William Hammond, Krzysztof Slowinski

Journal:

Langmuir

Year:

2006

Volume:

22

Pages

2426-2429

DOI:

10.1021/la053224+

Abstract:

The electrical conductance of ds-DNA duplexes containing 8−14 base pairs modified at both ends with a −(CH2)6−SH linker was measured in a buffered aqueous solution using electrochemically controlled distance tunneling spectroscopy. The tunneling experiment with self-complementary 5‘-(GC)n-3‘-(CH2)6−SH (n = 4−7) duplexes attached covalently to a gold STM tip and a Au(111) electrode shows a wide distribution of currents independent of the ds-DNA length. The voltage-induced horizontal orientation of ds-DNA within the junction results in decreased electrical conductance. The lower currents are also observed for ds-DNA molecules containing a single CA base mismatch.

© Molecular Junction Database | University of Southern California. All rights reserved.

bottom of page